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Hu2019 - Modeling Pancreatic Cancer Dynamics with Immunotherapy


ABSTRACT: This is a mathematical model of pancreatic cancer that includes descriptions of pancreatic cancer cells, pancreatic stellate cells, effector cells and tumor-promoting and tumor-suppressing cytokines to investigate the effects of immunotherapies on patient survival.

SUBMITTER: Johannes Meyer  

PROVIDER: BIOMD0000000792 | BioModels | 2019-08-13

REPOSITORIES: BioModels

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Modeling Pancreatic Cancer Dynamics with Immunotherapy.

Hu Xiaochuan X   Ke Guoyi G   Jang Sophia R-J SR  

Bulletin of mathematical biology 20190306 6


We develop a mathematical model of pancreatic cancer that includes pancreatic cancer cells, pancreatic stellate cells, effector cells and tumor-promoting and tumor-suppressing cytokines to investigate the effects of immunotherapies on patient survival. The model is first validated using the survival data of two clinical trials. Local sensitivity analysis of the parameters indicates there exists a critical activation rate of pro-tumor cytokines beyond which the cancer can be eradicated if four ad  ...[more]

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