Benary2019 - Controlling NFKB dynamics by B-TrCP
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ABSTRACT:
SUBMITTER: 
Krishna Kumar Tiwari
PROVIDER: BIOMD0000000794 | BioModels | 2024-09-02
REPOSITORIES: BioModels
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Controlling Nuclear NF-κB Dynamics by β-TrCP-Insights from a Computational Model.
Biomedicines 20190527 2
The canonical nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway regulates central processes in mammalian cells and plays a fundamental role in the regulation of inflammation and immunity. Aberrant regulation of the activation of the transcription factor NF-κB is associated with severe diseases such as inflammatory bowel disease and arthritis. In the canonical pathway, the inhibitor IκB suppresses NF-κB's transcriptional activity. NF-κB becomes active upon t ...[more]
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