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Benary2019 - Controlling NFKB dynamics by B-TrCP


ABSTRACT: its a mathematical model studying impact of b_TrCP on NFKB nuclear dynamics. This model is derived from Lipniacki2004 (PMID:15094015).

SUBMITTER: Krishna Kumar Tiwari  

PROVIDER: BIOMD0000000794 | BioModels | 2019-08-13

REPOSITORIES: BioModels

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Controlling Nuclear NF-κB Dynamics by β-TrCP-Insights from a Computational Model.

Benary Uwe U   Wolf Jana J  

Biomedicines 20190527 2


The canonical nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway regulates central processes in mammalian cells and plays a fundamental role in the regulation of inflammation and immunity. Aberrant regulation of the activation of the transcription factor NF-κB is associated with severe diseases such as inflammatory bowel disease and arthritis. In the canonical pathway, the inhibitor IκB suppresses NF-κB's transcriptional activity. NF-κB becomes active upon t  ...[more]

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