Park2019 - IL7 receptor signaling in T cells
Ontology highlight
ABSTRACT:
SUBMITTER: 
Johannes Meyer
PROVIDER: BIOMD0000000803 | BioModels | 2021-10-05
REPOSITORIES: BioModels
Publications
IL7 receptor signaling in T cells: A mathematical modeling perspective.
Park Jung-Hyun JH Waickman Adam T AT Reynolds Joseph J Castro Mario M Molina-París Carmen C
Wiley interdisciplinary reviews. Systems biology and medicine 20190528 5
Interleukin-7 (IL7) plays a nonredundant role in T cell survival and homeostasis, which is illustrated in the severe T cell lymphopenia of IL7-deficient mice, or demonstrated in animals or humans that lack expression of either the IL7Rα or γ <sub>c</sub> chain, the two subunits that constitute the functional IL7 receptor. Remarkably, IL7 is not expressed by T cells themselves, but produced in limited amounts by radio-resistant stromal cells. Thus, T cells need to constantly compete for IL7 to su ...[more]
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