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Kronik2008 - Improving alloreactive CTL immunotherapy for malignant gliomas using a simulation model of their interactive dynamics


ABSTRACT: This mathematical model describes interactions between glioma tumors and the immune system that may occur following direct intra-tumoral administration of ex-vivo activated alloreactive cytotoxic-T-lymphocytes (aCTLs) as part of adoptive immunotherapy. The model includes descriptions of aCTL, neoplastic cells, MHC class I and II molecules, TGF-beta and IFN-gamma.

SUBMITTER: Johannes Meyer  

PROVIDER: BIOMD0000000808 | BioModels | 2019-09-09

REPOSITORIES: BioModels

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Improving alloreactive CTL immunotherapy for malignant gliomas using a simulation model of their interactive dynamics.

Kronik Natalie N   Kogan Yuri Y   Vainstein Vladimir V   Agur Zvia Z  

Cancer immunology, immunotherapy : CII 20070907 3


Glioblastoma (GBM), a highly aggressive (WHO grade IV) primary brain tumor, is refractory to traditional treatments, such as surgery, radiation or chemotherapy. This study aims at aiding in the design of more efficacious GBM therapies. We constructed a mathematical model for glioma and the immune system interactions, that may ensue upon direct intra-tumoral administration of ex vivo activated alloreactive cytotoxic-T-lymphocytes (aCTL). Our model encompasses considerations of the interactive dyn  ...[more]

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