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Lee2008 - ERK and PI3K signal integration by Myc


ABSTRACT: Mechanisitc model of PI3K and ERK signal integration by Myc. ERK and PI3K regulated Myc satbility by phosphorylating the same. (PMID:18463697)

SUBMITTER: Krishna Kumar Tiwari  

PROVIDER: BIOMD0000000818 | BioModels | 2019-09-19

REPOSITORIES: BioModels

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Publications

Sensing and integration of Erk and PI3K signals by Myc.

Lee Tae T   Yao Guang G   Nevins Joseph J   You Lingchong L  

PLoS computational biology 20080229 2


The transcription factor Myc plays a central role in regulating cell-fate decisions, including proliferation, growth, and apoptosis. To maintain a normal cell physiology, it is critical that the control of Myc dynamics is precisely orchestrated. Recent studies suggest that such control of Myc can be achieved at the post-translational level via protein stability modulation. Myc is regulated by two Ras effector pathways: the extracellular signal-regulated kinase (Erk) and phosphatidylinositol 3-ki  ...[more]

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