Dhawan2019 - Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network
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SUBMITTER: 
Johannes Meyer
PROVIDER: BIOMD0000000841 | BioModels | 2019-11-01
REPOSITORIES: BioModels
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Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network.
Dhawan Andrew A Harris Adrian L AL Buffa Francesca M FM Scott Jacob G JG
Journal of theoretical biology 20181030
Oscillations are crucial to the normal function of living organisms, across a wide variety of biological processes. In eukaryotes, oscillatory dynamics are thought to arise from interactions at the protein and RNA levels; however, the role of non-coding RNA in regulating these dynamics remains understudied. In this work, we show how non-coding RNA acting as microRNA (miRNA) sponges in a conserved miRNA - transcription factor feedback motif, can give rise to oscillatory behaviour, and how to test ...[more]
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