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Jenner2019 - Oncolytic virotherapy for tumours following a Gompertz growth law

ABSTRACT: This is a mathematical model using a Gompertz growth law to describe the in vivo dynamics of a cancer under treatment with an oncolytic virus.

SUBMITTER: Johannes Meyer

PROVIDER: BIOMD0000000850 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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	BIOMD0000000850?filename=Jenner2019-biopax2.owl	Owl
	BIOMD0000000850?filename=Jenner2019-biopax3.owl	Owl
	BIOMD0000000850?filename=Jenner2019-matlab.m	Other
	BIOMD0000000850?filename=Jenner2019-octave.m	Other
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Oncolytic virotherapy for tumours following a Gompertz growth law.

Jenner Adrianne L AL Kim Peter S PS Frascoli Federico F

Journal of theoretical biology 20190807

Oncolytic viruses are genetically engineered to treat growing tumours and represent a very promising therapeutic strategy. Using a Gompertz growth law, we discuss a model that captures the in vivo dynamics of a cancer under treatment with an oncolytic virus. With the aid of local stability analysis and bifurcation plots, the typical interactions between virus and tumour are investigated. The system shows a singular equilibrium and a number of nonlinear behaviours that have interesting biological ...[more]

PMID: 31400344

Publication: 1/2

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