Andersen2017 - Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development
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ABSTRACT:
SUBMITTER: 
Johannes Meyer
PROVIDER: BIOMD0000000852 | BioModels | 2019-11-12
REPOSITORIES: BioModels
Publications
Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development.
Andersen Morten M Sajid Zamra Z Pedersen Rasmus K RK Gudmand-Hoeyer Johanne J Ellervik Christina C Skov Vibe V Kjær Lasse L Pallisgaard Niels N Kruse Torben A TA Thomassen Mads M Troelsen Jesper J Hasselbalch Hans Carl HC Ottesen Johnny T JT
PloS one 20170831 8
The chronic Philadelphia-negative myeloproliferative neoplasms (MPNs) are acquired stem cell neoplasms which ultimately may transform to acute myelogenous leukemia. Most recently, chronic inflammation has been described as an important factor for the development and progression of MPNs in the biological continuum from early cancer stage to the advanced myelofibrosis stage, the MPNs being described as "A Human Inflammation Model for Cancer Development". This novel concept has been built upon clin ...[more]
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