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Gray2016 - The Akt switch model

ABSTRACT: This is a simple, linear, four-compartment ordinary differential equation (ODE) model Akt activation that tracks both the phosphorylation state and the physical location (cytosol, plasma membrane) of Akt.

SUBMITTER: Johannes Meyer

PROVIDER: BIOMD0000000854 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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			Action	DRS
	BIOMD0000000854?filename=Gray2016-biopax2.owl	Owl
	BIOMD0000000854?filename=Gray2016-biopax3.owl	Owl
	BIOMD0000000854?filename=Gray2016-matlab.m	Other
	BIOMD0000000854?filename=Gray2016-octave.m	Other
	BIOMD0000000854?filename=Gray2016.cps	Other

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Publications

The Akt switch model: Is location sufficient?

Gray Catheryn W CW Coster Adelle C F AC

Journal of theoretical biology 20160315

Akt/PKB is a biochemical regulator that functions as an important cross-talk node between several signalling pathways in the mammalian cell. In particular, Akt is a key mediator of glucose transport in response to insulin. The phosphorylation (activation) of only a small percentage of the Akt pool of insulin-sensitive cells results in maximal translocation of glucose transporter 4 (GLUT4) to the plasma membrane (PM). This enables the diffusion of glucose into the cell. The dysregulation of Akt s ...[more]

PMID: 26992575

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Cavin-3 Dictates the Balance Between ERK and Akt Signaling

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Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling

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Akt-Induced Mitochondrial Dysfunction in the Heart

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