Ontology highlight
ABSTRACT:
SUBMITTER: Johannes Meyer
PROVIDER: BIOMD0000000863 | BioModels | 2019-11-14
REPOSITORIES: BioModels
Kosinsky Yuri Y Dovedi Simon J SJ Peskov Kirill K Voronova Veronika V Chu Lulu L Tomkinson Helen H Al-Huniti Nidal N Stanski Donald R DR Helmlinger Gabriel G
Journal for immunotherapy of cancer 20180227 1
<h4>Background</h4>Numerous oncology combination therapies involving modulators of the cancer immune cycle are being developed, yet quantitative simulation models predictive of outcome are lacking. We here present a model-based analysis of tumor size dynamics and immune markers, which integrates experimental data from multiple studies and provides a validated simulation framework predictive of biomarkers and anti-tumor response rates, for untested dosing sequences and schedules of combined radia ...[more]