Ontology highlight
ABSTRACT:
SUBMITTER: Johannes Meyer
PROVIDER: BIOMD0000000867 | BioModels | 2019-11-18
REPOSITORIES: BioModels
Coulibaly Anna A Bettendorf Anja A Kostina Ekaterina E Figueiredo Ana Sofia AS Velásquez Sonia Y SY Bock Hans-Georg HG Thiel Manfred M Lindner Holger A HA Barbarossa Maria Vittoria MV
Frontiers in immunology 20191016
Natural killer (NK) cells belong to the first line of host defense against infection and cancer. Cytokines, including interleukin-15 (IL-15), critically regulate NK cell activity, resulting in recognition and direct killing of transformed and infected target cells. NK cells have to adapt and respond in inflamed and often hypoxic areas. Cellular stabilization and accumulation of the transcription factor hypoxia-inducible factor-1α (HIF-1α) is a key mechanism of the cellular hypoxia response. At t ...[more]