Dataset Information


Coulibaly2019 - Interleukin-15 Signaling in HIF-1a Regulation in Natural Killer Cells

ABSTRACT: This is a mathematical model comprised of non-linear ordinary differential equations describing the dynamic relationship between hypoxia-inducible factor-1 alpha (HIF-1a) mRNA, HIF-1a protein, and interleukin-15-mediated upstream signalling events in natural killer cells from human blood. Regulatory expressions are also included for mammalian target of rapamycin (mTOR), nuclear factor-kappa beta, and signal transducer and activator of transcription 3 (STAT3).

SUBMITTER: Johannes Meyer  

PROVIDER: BIOMD0000000867 | BioModels | 2019-11-18


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Interleukin-15 Signaling in HIF-1α Regulation in Natural Killer Cells, Insights Through Mathematical Models.

Coulibaly Anna A   Bettendorf Anja A   Kostina Ekaterina E   Figueiredo Ana Sofia AS   Velásquez Sonia Y SY   Bock Hans-Georg HG   Thiel Manfred M   Lindner Holger A HA   Barbarossa Maria Vittoria MV  

Frontiers in immunology 20191016

Natural killer (NK) cells belong to the first line of host defense against infection and cancer. Cytokines, including interleukin-15 (IL-15), critically regulate NK cell activity, resulting in recognition and direct killing of transformed and infected target cells. NK cells have to adapt and respond in inflamed and often hypoxic areas. Cellular stabilization and accumulation of the transcription factor hypoxia-inducible factor-1α (HIF-1α) is a key mechanism of the cellular hypoxia response. At t  ...[more]

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