Models

Dataset Information

0

DePillis2008 - Optimal control of mixed immunotherapy and chemotherapy of tumors


ABSTRACT: <notes xmlns="http://www.sbml.org/sbml/level2/version4"> <body xmlns="http://www.w3.org/1999/xhtml"> <pre>Optimal control of mixed immunotherapy and chemotherapy of tumors Lisette Depillis, K. R. Fister , W. Gu, Tiffany Head, Kenny Maples, Todd Neal, Anand Murugan and Kenji Kozai Abstract We investigate a mathematical population model of tumor-immune interactions. Thepopulations involved are tumor cells, specific and non-specific immune cells, and con-centrations of therapeutic treatments. We establish the existence of an optimal con-trol for this model and provide necessary conditions for the optimal control triple forsimultaneous application of chemotherapy, tumor infiltrating lymphocyte (TIL) ther-apy, and interleukin-2 (IL-2) treatment. We discuss numerical results for the combina-tion of the chemo-immunotherapy regimens. We find that the qualitative nature of ourresults indicates that chemotherapy is the dominant intervention with TIL interactingin a complementary fashion with the chemotherapy. However, within the optimal con-trol context, the interleukin-2 treatment does not become activated for the estimatedparameter ranges.

SUBMITTER: Mohammad Umer Sharif Shohan  

PROVIDER: BIOMD0000000913 | BioModels | 2020-01-21

REPOSITORIES: BioModels

Similar Datasets

2020-01-16 | MODEL2001160002 | BioModels
| E-GEOD-51414 | biostudies-arrayexpress
2013-12-03 | GSE51414 | GEO
2020-03-06 | MODEL2003060001 | BioModels
2020-01-03 | BIOMD0000000897 | BioModels
2020-01-20 | MODEL2001160001 | BioModels
2021-09-06 | BIOMD0000001042 | BioModels
2019-06-11 | PXD008127 | Pride
2021-10-01 | BIOMD0000000777 | BioModels
2020-01-20 | MODEL2001200002 | BioModels