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Evans2004 - Cell based mathematical model of topotecan

ABSTRACT: A two compartment mathematical model of the antineoplastic compound topotecan

SUBMITTER: Matthew Roberts

PROVIDER: BIOMD0000000945 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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	BIOMD0000000945?filename=Evans2004-biopax2.owl	Owl
	BIOMD0000000945?filename=Evans2004-biopax3.owl	Owl
	BIOMD0000000945?filename=Evans2004-matlab.m	Other
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Publications

A mathematical model for the in vitro kinetics of the anti-cancer agent topotecan.

Evans Neil D ND Errington Rachel J RJ Shelley Michael M Feeney Graham P GP Chapman Michael J MJ Godfrey Keith R KR Smith Paul J PJ Chappell Michael J MJ

Mathematical biosciences 20040601 2

In this paper a compartmental modelling approach is applied to provide a mathematical description of the activity of the anti-cancer agent topotecan, and delivery to its nuclear DNA target following administration. The activity of topotecan in defined buffers is first modelled using a linear two compartment model that then forms the basis of a cell based model for drug activity in live cell experiments. An identifiability analysis is performed before parameter estimation to ensure that the model ...[more]

PMID: 15094319

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