Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mitrophanov2015 - Simulating extended Hockin Blood Coagulation Model under varied pH

ABSTRACT: Mathematical model of the blood coagulation cascade with new kinetic rates to simulate acidosis. Extended Hockin2002 model. Reused Mitrophanov2011 model with new parameters k: 5, 6, 7, 10, 15, 16, 17, 22, 26, 31, 32, 43 and 44.

SUBMITTER: Matthew Roberts

PROVIDER: BIOMD0000000951 | BioModels | 2018-06-27

REPOSITORIES: BioModels

ACCESS DATA

Json Xml

Publications

Mechanistic Modeling of the Effects of Acidosis on Thrombin Generation.

Mitrophanov Alexander Y AY Rosendaal Frits R FR Reifman Jaques J

Anesthesia and analgesia 20150801 2

<h4>Background</h4>Acidosis, a frequent complication of trauma and complex surgery, results from tissue hypoperfusion and IV resuscitation with acidic fluids. While acidosis is known to inhibit the function of distinct enzymatic reactions, its cumulative effect on the blood coagulation system is not fully understood. Here, we use computational modeling to test the hypothesis that acidosis delays and reduces the amount of thrombin generation in human blood plasma. Moreover, we investigate the sen ...[more]

PMID: 25839182

Similar Datasets

Whole-genome bisulfite sequencing (WGBS) of Medicago truncatula developmental and mature embryos at four seed developmental stages produced at optimal (20°C) or heat stress conditions (26°C).

Project description:We analysed the methylated cytocines in gDNA sequence of Medicago (A17) embryos during seed maturation concerning Heat Stress. Embryos were harvested at four developemental stages (called S1 to S4): 17, 26, 36 and 44 days after polination (DAP) at 20°C and 14, 17, 22 and 28 days after polination (DAP) at 26°C.

2022-04-30 | GSE201335 | GEO

Whole blood microRNA expression profiles in human non-small cell lung adenocarcinoma

Project description:Fifth generation Exiqon® locked nucleic acid miRCURY™ LNA microarrays were used to profile the expression of microRNAs in whole blood of patients with non-small cell lung adenocarcinoma and of clinically relevant controls without the disease. Total RNA was isolated from whole blood of 22 cases and 23 controls. Sample RNA was labeled with the Cy3-like Hy3™ dye, mixed with a human universal reference RNA labeled with the Cy5-like Hy5™ dye, and hybridized to two-color miRCURY™ arrays from Exiqon®. - Disease: Lung adenocarcinoma: samples 1, 2, 3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14, 16, 17, 18, 20, 21, 22, 23, 24, 25 - Disease: No cancer: samples 26, 27, 28, 29, 30, 31, 32, 33, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49

2011-05-20 | E-GEOD-27486 | biostudies-arrayexpress

Clostridium acetobutylicum ATCC 824 time course with Agilent Arrays

Project description:Using our newly designed C. acetobutylicum arrays we analyzed the mRNA changes during a time course experiment (up to 66 h) paying special attention on the study of the late timepoints. Keywords: time course Samples were taken from a Bioflow II reactor at 6, 7, 8, 9, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 44, 48, 54, 58, and 66 hrs after bioreactor inoculation. Two slides per timepoint were hybridized on a dye swap configuration. The control mRNA was generated by combining samples taken at 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 44, 48, 54, 58, and 66 hrs after bioreactor inoculation. For timepoints 6, 8, 14, 32, 38, 66 our internal quality control check suggested a larger than normal variation of the intensities in the control channel and a third slide was hybridized. The discarded slides are GSM141189, GSM141203, GSM141222, GSM141229 and GSM141242.

2010-05-25 | E-GEOD-6094 | biostudies-arrayexpress

Simulating visibility under reduced acuity and contrast sensitivity.

Project description: Not available

| S-EPMC5558613 | biostudies-other

Outcomes of Allogeneic Hematopoietic Cell Transplantation in Adults with fusions associated with Ph-like ALL

Project description:Allogenic hematopoietic cell transplantation (alloHCT) is a well-established curative modality for adults with high-risk ALL; yet large data describing alloHCT outcomes in Philadelphia (Ph)-like ALL is lacking. We retrospectively analyzed archived DNA samples from consecutive adults with B-cell Ph-negative ALL who underwent alloHCT in complete remission (CR) (n= 127) at our center between 2006 and 2020. Identification of fusions associated with Ph-like were performed using accumulative results from RNAseq, conventional cytogenetics, FISH, and whole genome array studies. Fusions associated with Ph-like were detected in 56 (44%) patients, of whom 38 were carrying CRLF2r; and the rest (n=18) were non-CRLF2r. Compared to other non-Ph-like (n=71), patients with fusions associated with Ph-like ALL were more frequently Hispanic (P=0.008), less frequently carried high-risk cytogenetics (P<0.001), and more likely to receive blinatumomab prior to HCT (P=0.019). With the median follow-up of 3.5 years, patients with Ph-like ALL fusions had comparable post-transplant outcomes compared to other B-cell ALL: 3-year relapse-free survival (RFS) [41% vs. 44%, P=0.36], overall survival (OS) [51% vs. 50%, P=0.59] and relapse [37% vs. 31%, P=0.47]. In multivariable analysis, age (P= 0.023), disease status at the time of transplant (P<0.001), and donor type (P=0.015) influenced OS. RFS (primary endpoint) was significantly influenced by disease status (P<0.001) and conditioning regimen intensity (P=0.014). Relapse rate was associated with disease status (P=0.028) and conditioning regimen intensity (P=0.028). In conclusion, our data suggest that alloHCT consolidation results in similarly favorable survival outcomes in adult patients with Ph-like fusions and other high-risk B-cell ALL.

2022-08-01 | E-MTAB-11954 | biostudies-arrayexpress

Mitrophanov2013 - Simulation of Hockin Blood Coagulation Model under reduced temperature

Project description:Blood coagulation model using an updated Hockin2002 model. New reactions for factor X and V activation by IXa and mIIa respectively (reactions R28 and R29, parameters k43 and k44). Changes to parameters k32 and k38 (appendix not found for cited reference [Danforth 2009] so parameters from Mitrophanov2011 were used). Model introduces formula for adjusting kinetic rates for reduced temperatures.

2018-06-25 | MODEL1806250002 | BioModels

1704225

Project description:A new HLA-B*44 variant

| PRJEB23308 | ENA

Ph-like acute lymphoblastic leukemia in adults is characterized by IgH-CRFL2 and JAK2 mutations and poor prognosis [HG-U133A]

Project description:Philadelphia-like B-cell precursor acute lymphoblastic leukemia (Ph-like ALL) is characterized by distinct genetic alterations and inferior prognosis in children and younger adults. The purpose of this study was the genetic and clinical characterization of Ph-like ALL in adults. Among 207 adult B-cell precursor ALL patients, 26 (13%) were classified as Ph-like using Affymetrix microarrays. The incidence of this subtype was 25% among 105 B-cell precursor ALL patients negative for BCR-ABL1 and MLL-translocations (B-other). All patients with IgH-CRLF2 translocation (38% vs 0%; p=0.002) or mutations in JAK2 (44% vs. 0%; p<0.001) were exclusively found in the Ph-like subgroup. Clinical and outcome analyses were restricted to patients treated within GMALL trials 06/99 and 07/03 (n=107). The complete remission (CR) rate after induction was 100% for Ph-like (n=19) and B-other patients (n=40). After induction, significantly fewer Ph-like patients reached molecular CR (33% vs 79%; p=0.01). At 5 years, the Ph-like ALL subgroup had a lower probability of continuous CR (24% vs 62%; p<0.001) and overall survival (22% vs 64%; p=0.006) compared to B-other ALL patients. Subsequent analysis led to a clinically applicable algorithm identifying this patient subset with a specificity of 100%. Our study is the first to demonstrate that the profile of genetic events in adult Ph-like ALL resembles pediatric Ph-like ALL and differs from B-other ALL. The Ph-like phenotype associates with inferior outcomes in intensively treated adult ALL patients. Ph-like adult ALL should be recognized as a distinct, high-risk entity and further research on improved diagnostic and therapeutic approaches is needed.

2017-02-28 | GSE66004 | GEO

Ph-like acute lymphoblastic leukemia in adults is characterized by IgH-CRFL2 and JAK2 mutations and poor prognosis [HG-U133_Plus_2]

2017-02-28 | GSE66002 | GEO

Ph-like acute lymphoblastic leukemia in adults is characterized by IgH-CRFL2 and JAK2 mutations and poor prognosis [HG-U133B]

2017-02-28 | GSE66005 | GEO