Kok2020 - IFNalpha-induced signaling in Huh7.5 cells
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ABSTRACT:
SUBMITTER: 
Marcus Rosenblatt
PROVIDER: BIOMD0000000959 | BioModels | 2020-08-17
REPOSITORIES: BioModels
Publications
Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction.
Kok Frédérique F Rosenblatt Marcus M Teusel Melissa M Nizharadze Tamar T Gonçalves Magalhães Vladimir V Dächert Christopher C Maiwald Tim T Vlasov Artyom A Wäsch Marvin M Tyufekchieva Silvana S Hoffmann Katrin K Damm Georg G Seehofer Daniel D Boettler Tobias T Binder Marco M Timmer Jens J Schilling Marcel M Klingmüller Ursula U
Molecular systems biology 20200701 7
Tightly interlinked feedback regulators control the dynamics of intracellular responses elicited by the activation of signal transduction pathways. Interferon alpha (IFNα) orchestrates antiviral responses in hepatocytes, yet mechanisms that define pathway sensitization in response to prestimulation with different IFNα doses remained unresolved. We establish, based on quantitative measurements obtained for the hepatoma cell line Huh7.5, an ordinary differential equation model for IFNα signal tran ...[more]
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