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Dasgupta2020 - Reduced model of receptor clusturing and aggregation

ABSTRACT: a simple kinetic mass-action-law-based model could be utilized to adequately describe clustering in response to activation both in 2D and in 3D

SUBMITTER: Krishna Kumar Tiwari

PROVIDER: BIOMD0000000973 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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			Action	DRS
	BIOMD0000000973?filename=Dasgupta2020-biopax2.owl	Owl
	BIOMD0000000973?filename=Dasgupta2020-biopax3.owl	Owl
	BIOMD0000000973?filename=Dasgupta2020-matlab.m	Other
	BIOMD0000000973?filename=Dasgupta2020-octave.m	Other
	BIOMD0000000973?filename=Dasgupta2020.cps	Other

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Publications

Development of a Simple Kinetic Mathematical Model of Aggregation of Particles or Clustering of Receptors.

Garzon Dasgupta Andrei K AK Martyanov Alexey A AA Filkova Aleksandra A AA Panteleev Mikhail A MA Sveshnikova Anastasia N AN

Life (Basel, Switzerland) 20200626 6

The process of clustering of plasma membrane receptors in response to their agonist is the first step in signal transduction. The rate of the clustering process and the size of the clusters determine further cell responses. Here we aim to demonstrate that a simple 2-differential equation mathematical model is capable of quantitative description of the kinetics of 2D or 3D cluster formation in various processes. Three mathematical models based on mass action kinetics were considered and compared ...[more]

PMID: 32604803

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