Models,Multiomics

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Strasen2018 - TGFb SMAD Signalling Class 2


ABSTRACT: Model depicting class 2 signaling class observed upon stimulation with 100 pM TGFβ1.

SUBMITTER: uddipan sarma  

PROVIDER: BIOMD0000000999 | BioModels | 2021-02-24

REPOSITORIES: BioModels

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Publications

Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.

Strasen Jette J   Sarma Uddipan U   Jentsch Marcel M   Bohn Stefan S   Sheng Caibin C   Horbelt Daniel D   Knaus Petra P   Legewie Stefan S   Loewer Alexander A  

Molecular systems biology 20180125 1


The cytokine TGFβ provides important information during embryonic development, adult tissue homeostasis, and regeneration. Alterations in the cellular response to TGFβ are involved in severe human diseases. To understand how cells encode the extracellular input and transmit its information to elicit appropriate responses, we acquired quantitative time-resolved measurements of pathway activation at the single-cell level. We established dynamic time warping to quantitatively compare signaling dyna  ...[more]

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