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Intosalmi2015 - Th17 core network model

ABSTRACT: a dynamic description for the core molecular mechanisms steering Th17 cell differentiation and use mathematical modeling to quantitatively predict the resulting molecular dynamics

SUBMITTER: Krishna Kumar Tiwari

PROVIDER: BIOMD0000001004 | BioModels | 2021-02-26

REPOSITORIES: BioModels

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Analyzing Th17 cell differentiation dynamics using a novel integrative modeling framework for time-course RNA sequencing data.

Intosalmi Jukka J Ahlfors Helena H Rautio Sini S Mannerstöm Henrik H Chen Zhi Jane ZJ Lahesmaa Riitta R Stockinger Brigitta B Lähdesmäki Harri H

BMC systems biology 20151117

<h4>Background</h4>The differentiation of naive CD 4(+) helper T (Th) cells into effector Th17 cells is steered by extracellular cytokines that activate and control the lineage specific transcriptional program. While the inducing cytokine signals and core transcription factors driving the differentiation towards Th17 lineage are well known, detailed mechanistic interactions between the key components are poorly understood.<h4>Results</h4>We develop an integrative modeling framework which combine ...[more]

PMID: 26578352

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