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Raman2005 - Mycolic acid pathway of M. tuberculosis

ABSTRACT: The mycobacterial cell wall is a distinctive thick layer that protects the tubercle bacillus from general antibiotics and the host’s immune system. Mycolic acids, which are long-chain α-alkyl-β-hydroxy fatty acids, are the major constituents of this protective layer, and their synthesis has been shown to be critical for the survival of M. tuberculosis. This model captures the mycolic acid pathway in M. tuberculosis with 197 metabolites participating in 219 reactions catalysed by 28 proteins. The model helps in the rational identification of potential anti-tubercular drug targets.

SUBMITTER: Nicolas Le Novère

PROVIDER: BIOMD0000001046 | BioModels | 2023-11-24

REPOSITORIES: BioModels

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Flux balance analysis of mycolic acid pathway: targets for anti-tubercular drugs.

Raman Karthik K Rajagopalan Preethi P Chandra Nagasuma N

PLoS computational biology 20051014 5

Mycobacterium tuberculosis is the focus of several investigations for design of newer drugs, as tuberculosis remains a major epidemic despite the availability of several drugs and a vaccine. Mycobacteria owe many of their unique qualities to mycolic acids, which are known to be important for their growth, survival, and pathogenicity. Mycolic acid biosynthesis has therefore been the focus of a number of biochemical and genetic studies. It also turns out to be the pathway inhibited by front-line a ...[more]

PMID: 16261191

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