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Adlung2021 - Cell-to-cell variability in JAK2/STAT5 pathway

ABSTRACT: A mathematical model for cell-to-cell variability in JAK2/STAT5 pathway components and cytoplasmic volumes defines survival threshold in erythroid progenitor cells

SUBMITTER: Marcel Schilling

PROVIDER: BIOMD0000001077 | BioModels | 2024-01-26

REPOSITORIES: BioModels

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Cell-to-cell variability in JAK2/STAT5 pathway components and cytoplasmic volumes defines survival threshold in erythroid progenitor cells.

Adlung Lorenz L Stapor Paul P Tönsing Christian C Schmiester Leonard L Schwarzmüller Luisa E LE Postawa Lena L Wang Dantong D Timmer Jens J Klingmüller Ursula U Hasenauer Jan J Schilling Marcel M

Cell reports 20210801 6

Survival or apoptosis is a binary decision in individual cells. However, at the cell-population level, a graded increase in survival of colony-forming unit-erythroid (CFU-E) cells is observed upon stimulation with erythropoietin (Epo). To identify components of Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5) signal transduction that contribute to the graded population response, we extended a cell-population-level model calibrated with experimental data to study the ...[more]

PMID: 34380040

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