ABSTRACT:
This a model from the article:
Dynamical description of sinoatrial node pacemaking: improved mathematical model
for primary pacemaker cell.
Kurata Y, Hisatome I, Imanishi S, Shibamoto T. Am J Physiol Heart Circ Physiol
2002 Nov;283(5):H2074-101 12384487
,
Abstract:
We developed an improved mathematical model for a single primary pacemaker cell
of the rabbit sinoatrial node. Original features of our model include 1)
incorporation of the sustained inward current (I(st)) recently identified in
primary pacemaker cells, 2) reformulation of voltage- and Ca(2+)-dependent
inactivation of the L-type Ca(2+) channel current (I(Ca,L)), 3) new expressions
for activation kinetics of the rapidly activating delayed rectifier K(+) channel
current (I(Kr)), and 4) incorporation of the subsarcolemmal space as a diffusion
barrier for Ca(2+). We compared the simulated dynamics of our model with those
of previous models, as well as with experimental data, and examined whether the
models could accurately simulate the effects of modulating sarcolemmal ionic
currents or intracellular Ca(2+) dynamics on pacemaker activity. Our model
represents significant improvements over the previous models, because it can 1)
simulate whole cell voltage-clamp data for I(Ca,L), I(Kr), and I(st); 2)
reproduce the waveshapes of spontaneous action potentials and ionic currents
during action potential clamp recordings; and 3) mimic the effects of channel
blockers or Ca(2+) buffers on pacemaker activity more accurately than the
previous models.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Kurata Y, Hisatome I, Imanishi S, Shibamoto T. (2002) - version05
The original CellML model was created by:
Noble, Penny,
penny.noble@dpag.ox.ac.uk
The University of Oxford
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Vijayalakshmi Chelliah 
