ABSTRACT:
This a model from the article:
One-dimensional rabbit sinoatrial node models: benefits and limitations.
Garny A, Kohl P, Hunter PJ, Boyett MR, Noble D. J Cardiovasc Electrophysiol
2003 Oct;14(10 Suppl):S121-32 14760914
,
Abstract:
INTRODUCTION: Cardiac multicellular modeling has traditionally focused on
ventricular electromechanics. More recently, models of the atria have started to
emerge, and there is much interest in addressing sinoatrial node structure and
function. METHODS AND RESULTS: We implemented a variety of one-dimensional
sinoatrial models consisting of descriptions of central, transitional, and
peripheral sinoatrial node cells, as well as rabbit or human atrial cells. These
one-dimensional models were implemented using CMISS on an SGI Origin 2000
supercomputer. Intercellular coupling parameters recorded in experimental
studies on sinoatrial node and atrial cell-pairs under-represent the
electrotonic interactions that any cardiomyocyte would have in a
multidimensional setting. Unsurprisingly, cell-to-cell coupling had to be
scaled-up (by a factor of 5) in order to obtain a stable leading pacemaker site
in the sinoatrial node center. Further critical parameters include the gradual
increase in intercellular coupling from sinoatrial node center to periphery, and
the presence of electrotonic interaction with atrial cells. Interestingly, the
electrotonic effect of the atrium on sinoatrial node periphery is best described
as opposing depolarization, rather than necessarily hyperpolarizing, as often
assumed. CONCLUSION: Multicellular one-dimensional models of sinoatrial node and
atrium can provide useful insight into the origin and spread of normal cardiac
excitation. They require larger than "physiologic" intercellular conductivities
in order to make up for a lack of "anatomical" spatial scaling. Multicellular
models for more in-depth quantitative studies will require more realistic
anatomico-physiologic properties.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Garny A, Kohl P, Hunter PJ, Boyett MR, Noble D. (2003) - version05
The original CellML model was created by:
Noble, Penny, J
penny.noble@dpag.ox.ac.uk
Oxford University
Department of Physiology, Anatomy & Genetics
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Vijayalakshmi Chelliah 
