ABSTRACT:
This a model from the article:
Rhythmic secretion of prolactin in rats: action of oxytocin coordinated by
vasoactive intestinal polypeptide of suprachiasmatic nucleus origin.
Egli M, Bertram R, Sellix MT, Freeman ME. Endocrinology
2004 Jul;145(7):3386-94 15033917
,
Abstract:
Prolactin (PRL) is secreted from lactotrophs of the anterior pituitary gland of
rats in a unique pattern in response to uterine cervical stimulation (CS) during
mating. Surges of PRL secretion occur in response to relief from hypothalamic
dopaminergic inhibition and stimulation by hypothalamic releasing neurohormones.
In this study, we characterized the role of oxytocin (OT) in this system and the
involvement of vasoactive intestinal polypeptide (VIP) from the suprachiasmatic
nucleus (SCN) in controlling OT and PRL secretion of CS rats. The effect of OT
on PRL secretion was demonstrated in cultured lactotrophs showing simultaneous
enhanced secretion rate and increased intracellular Ca(2+). Neurosecretory OT
cells of the hypothalamic paraventricular nucleus that express VIP receptors
were identified by using immunocytochemical techniques in combination with the
retrogradely transported neuronal tracer Fluoro-Gold (iv injected). OT
measurements of serial blood samples obtained from ovariectomized (OVX) CS rats
displayed a prominent increase at the time of the afternoon PRL peak. The
injection of VIP antisense oligonucleotides into the SCN abolished the afternoon
increase of OT and PRL in CS-OVX animals. These findings suggest that VIP from
the SCN contributes to the regulation of OT and PRL secretion in CS rats. We
propose that in CS rats the regulatory mechanism(s) for PRL secretion comprise
coordinated action of neuroendocrine dopaminergic and OT cells, both governed by
the daily rhythm of VIP-ergic output from the SCN. This hypothesis is
illustrated with a mathematical model.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Egli M, Bertram R, Sellix MT, Freeman ME. (2004) - version02
The original CellML model was created by:
Lloyd, Catherine, May
c.lloyd@aukland.ac.nz
The University of Auckland
The Bioengineering Institute
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Vijayalakshmi Chelliah 
