ABSTRACT:
This a model from the article:
Mathematical modelling of calcium wave propagation in mammalian airway
epithelium: evidence for regenerative ATP release.
Warren NJ, Tawhai MH, Crampin EJ. Exp Physiol
2010 Jan;95(1):232-49 19700517
,
Abstract:
Airway epithelium has been shown to exhibit intracellular calcium waves after
mechanical stimulation. Two classes of mechanism have been proposed to explain
calcium wave propagation: diffusion through gap junctions of the intracellular
messenger inositol 1,4,5-trisphosphate (IP3), and diffusion of paracrine
extracellular messengers such as ATP. We have used single cell recordings of
airway epithelium to parameterize a model of an airway epithelial cell. This was
then incorporated into a spatial model of a cell culture where both mechanisms
for calcium wave propagation are possible. It is shown that a decreasing return
on the radius of Ca2+ wave propagation is achieved as the amount of ATP released
from the stimulated cell increases. It is therefore shown that for a Ca2+ wave
to propagate large distances, a significant fraction of the intracellular ATP
pool would be required to be released. Further to this, the radial distribution
of maximal calcium response from the stimulated cell does not produce the same
flat profile of maximal calcium response seen in experiential studies. This
suggests that an additional mechanism is important in Ca2+ wave propagation,
such as regenerative release of ATP from cells downstream of the stimulated
cell.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Warren NJ, Tawhai MH, Crampin EJ. (2009) - version=1.0
The original CellML model was created by:
Nic Warren
n.warren@auckland.ac.nz
The University of Auckland
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
Camille Laibe 
