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Zhuang2011 - Ecoli FBA with membrane economics


ABSTRACT: Zhuang2011 - Ecoli FBA with membrane economics Genome-scale metabolic model of Escherichia coli able to simulate respiro-fermentation. This model is described in the article: Economics of membrane occupancy and respiro-fermentation. Zhuang K, Vemuri GN, Mahadevan R Molecular Systems Biology. 2011; 7:500 Abstract: The simultaneous utilization of efficient respiration and inefficient fermentation even in the presence of abundant oxygen is a puzzling phenomenon commonly observed in bacteria, yeasts, and cancer cells. Despite extensive research, the biochemical basis for this phenomenon remains obscure. We hypothesize that the outcome of a competition for membrane space between glucose transporters and respiratory chain (which we refer to as economics of membrane occupancy) proteins influences respiration and fermentation. By incorporating a sole constraint based on this concept in the genome-scale metabolic model of Escherichia coli, we were able to simulate respiro-fermentation. Further analysis of the impact of this constraint revealed differential utilization of the cytochromes and faster glucose uptake under anaerobic conditions than under aerobic conditions. Based on these simulations, we propose that bacterial cells manage the composition of their cytoplasmic membrane to maintain optimal ATP production by switching between oxidative and substrate-level phosphorylation. These results suggest that the membrane occupancy constraint may be a fundamental governing constraint of cellular metabolism and physiology, and establishes a direct link between cell morphology and physiology. This model is hosted on BioModels Database and identified by: MODEL1105030000 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

SUBMITTER: Kai Zhuang  

PROVIDER: MODEL1105030000 | BioModels | 2005-01-01

REPOSITORIES: BioModels

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Economics of membrane occupancy and respiro-fermentation.

Zhuang Kai K   Vemuri Goutham N GN   Mahadevan Radhakrishnan R  

Molecular systems biology 20110621


The simultaneous utilization of efficient respiration and inefficient fermentation even in the presence of abundant oxygen is a puzzling phenomenon commonly observed in bacteria, yeasts, and cancer cells. Despite extensive research, the biochemical basis for this phenomenon remains obscure. We hypothesize that the outcome of a competition for membrane space between glucose transporters and respiratory chain (which we refer to as economics of membrane occupancy) proteins influences respiration an  ...[more]

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