Dataset Information

Jesty1993_ProteolyticPositiveFeedback

ABSTRACT: This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Michael Schubert

PROVIDER: MODEL1108260010 | BioModels | 2005-01-01

REPOSITORIES: BioModels

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			Action	DRS
	MODEL1108260010?filename=MODEL1108260010-biopax2.owl	Owl
	MODEL1108260010?filename=MODEL1108260010-biopax3.owl	Owl
	MODEL1108260010?filename=MODEL1108260010.m	Other
	MODEL1108260010?filename=MODEL1108260010.pdf	Pdf
	MODEL1108260010?filename=MODEL1108260010.png	Other

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Publications

Mathematical analysis of a proteolytic positive-feedback loop: dependence of lag time and enzyme yields on the initial conditions and kinetic parameters.

Jesty J J Beltrami E E Willems G G

Biochemistry 19930601 24

A model of a proteolytic positive-feedback loop, similar in general terms to feedback loops that occur in blood coagulation and other systems, has been examined by both explicit and numerical analysis. In this loop, modeled as a closed system, each enzyme (E1, E2) catalyzes the formation of the other from its respective zymogen (Z1, Z2), and both enzymes are subject to irreversible inhibition. The system shows three major characteristics. (1) No significant Z1 or Z2 activation occurs unless the ...[more]

PMID: 8512937

Dataset Information

Jesty1993_ProteolyticPositiveFeedback

Dataset's files

Publications

Mathematical analysis of a proteolytic positive-feedback loop: dependence of lag time and enzyme yields on the initial conditions and kinetic parameters.

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