Dataset Information

Chatterjee2010_BloodCoagulation

ABSTRACT: This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Michael Schubert

PROVIDER: MODEL1108260014 | BioModels | 2005-01-01

REPOSITORIES: BioModels

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			Action	DRS
	MODEL1108260014?filename=MODEL1108260014-biopax2.owl	Owl
	MODEL1108260014?filename=MODEL1108260014-biopax3.owl	Owl
	MODEL1108260014?filename=MODEL1108260014.m	Other
	MODEL1108260014?filename=MODEL1108260014.pdf	Pdf
	MODEL1108260014?filename=MODEL1108260014.png	Other

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Publications

Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood.

Chatterjee Manash S MS Denney William S WS Jing Huiyan H Diamond Scott L SL

PLoS computational biology 20100930 9

Blood function defines bleeding and clotting risks and dictates approaches for clinical intervention. Independent of adding exogenous tissue factor (TF), human blood treated in vitro with corn trypsin inhibitor (CTI, to block Factor XIIa) will generate thrombin after an initiation time (T(i)) of 1 to 2 hours (depending on donor), while activation of platelets with the GPVI-activator convulxin reduces T(i) to ∼20 minutes. Since current kinetic models fail to generate thrombin in the absence of ad ...[more]

PMID: 20941387

Dataset Information

Chatterjee2010_BloodCoagulation

Dataset's files

Publications

Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood.

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