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Mardinoglu2014 - Genome-scale metabolic model (HMR version 2.0) - generic human cell


ABSTRACT: No description

SUBMITTER: Adil Mardinoglu  

PROVIDER: MODEL1402200002 | BioModels | 2005-01-01

REPOSITORIES: BioModels

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Publications

Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease.

Mardinoglu Adil A   Agren Rasmus R   Kampf Caroline C   Asplund Anna A   Uhlen Mathias M   Nielsen Jens J  

Nature communications 20140101


Several liver disorders result from perturbations in the metabolism of hepatocytes, and their underlying mechanisms can be outlined through the use of genome-scale metabolic models (GEMs). Here we reconstruct a consensus GEM for hepatocytes, which we call iHepatocytes2322, that extends previous models by including an extensive description of lipid metabolism. We build iHepatocytes2322 using Human Metabolic Reaction 2.0 database and proteomics data in Human Protein Atlas, which experimentally val  ...[more]

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