Ontology highlight
ABSTRACT:
SUBMITTER: Alain Leblanc
PROVIDER: MODEL1406230000 | BioModels | 2014-09-15
REPOSITORIES: BioModels
Journal of virology 20090513 14
The cellular immune response to primary influenza virus infection is complex, involving multiple cell types and anatomical compartments, and is difficult to measure directly. Here we develop a two-compartment model that quantifies the interplay between viral replication and adaptive immunity. The fidelity of the model is demonstrated by accurately confirming the role of CD4 help for antibody persistence and the consequences of immune depletion experiments. The model predicts that drugs to limit ...[more]