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Rutkis2013 - Entner-Doudoroff pathway in Z.mobilis


ABSTRACT: The model corresponds to the third columns (model simulations) in tables 3 and 5 of publication (PMID: 24085837, DOI: 10.1099/mic.0.071340-0) Mathematical Definition symbol/abbreviation Mathematical symbols Keq Equilibrium constant Ki Inhibition constant Km Affinity constant v Predicted enzyme activities Vf Maximal enzyme activities under saturating substrate and activator conditions, and in the absence of inhibitors h Hill coefficient k Rate constant Abbreviations ACET Acetaldehyde ADH Alcohol dehydrogenase AK Adenylate kinase ATPcons ATP consuming reactions bPG 1,3-bisphosphoglycerate ENO Enolase ETOHcy Cytoplasmic ethanol ETOHex Extracellular ethanol ETOHexp Ethanol transport GAP Glyceraldehyde 3-phosphate GAPD Glyceraldehyde 3-phosphate dehydrogenase GF Glucose facilitator GK Glucokinase GLUCcy Cytoplasmic glucose GLUCex Extracellular glucose GLUC6P Glucose 6-phosphate GPD Glucose 6-phosphate dehydrogenase KDPG 2-keto-3-deoxy-6-phosphogluconate KDPGA 2-keto-3-deoxy-6-phosphogluconate aldolase PDC Pyruvate decarboxylase PEP Phosphoenolpyruvate PGD 6-phosphogluconate dehydratase PGK 3-phosphoglycerate kinase PGL 6-phosphogluconolactonase PGLACTON 6-phosphogluconolactone PGLUCONATE 6-phosphogluconate PGM Phosphoglycerate mutase P3G 3-phosphoglycerate P2G 2-phosphoglycerate PYK Pyruvate kinase PYR Pyruvate

SUBMITTER: Egils Stalidzans  

PROVIDER: MODEL1409050000 | BioModels | 2014-09-15

REPOSITORIES: BioModels

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Publications

Kinetic modelling of the Zymomonas mobilis Entner-Doudoroff pathway: insights into control and functionality.

Rutkis Reinis R   Kalnenieks Uldis U   Stalidzans Egils E   Fell David A DA  

Microbiology (Reading, England) 20131001 Pt 12


Zymomonas mobilis, an ethanol-producing bacterium, possesses the Entner-Doudoroff (E-D) pathway, pyruvate decarboxylase and two alcohol dehydrogenase isoenzymes for the fermentative production of ethanol and carbon dioxide from glucose. Using available kinetic parameters, we have developed a kinetic model that incorporates the enzymic reactions of the E-D pathway, both alcohol dehydrogenases, transport reactions and reactions related to ATP metabolism. After optimizing the reaction parameters wi  ...[more]

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