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Talemi2015 - Persistent telomere-associated DNA damage foci (TAF), a measure to predict cancer risks

ABSTRACT: A Robust Model of DNA Damage Dynamics. Rasgou Talemi and Schaber, 12.20.2014.

SUBMITTER: Soheil Rastgou Talemi

PROVIDER: MODEL1412200000 | BioModels | 2016-02-11

REPOSITORIES: BioModels

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Publications

Development of a robust DNA damage model including persistent telomere-associated damage with application to secondary cancer risk assessment.

Rastgou Talemi Soheil S Kollarovic Gabriel G Lapytsko Anastasiya A Schaber Jörg J

Scientific reports 20150911

Mathematical modelling has been instrumental to understand kinetics of radiation-induced DNA damage repair and associated secondary cancer risk. The widely accepted two-lesion kinetic (TLK) model assumes two kinds of double strand breaks, simple and complex ones, with different repair rates. Recently, persistent DNA damage associated with telomeres was reported as a new kind of DNA damage. We therefore extended existing versions of the TLK model by new categories of DNA damage and re-evaluated t ...[more]

PMID: 26359627

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