Ontology highlight
ABSTRACT:
SUBMITTER: Leif Väremo
PROVIDER: MODEL1503240000 | BioModels | 2016-02-10
REPOSITORIES: BioModels
Väremo Leif L Scheele Camilla C Broholm Christa C Mardinoglu Adil A Kampf Caroline C Asplund Anna A Nookaew Intawat I Uhlén Mathias M Pedersen Bente Klarlund BK Nielsen Jens J
Cell reports 20150430 6
Skeletal myocytes are metabolically active and susceptible to insulin resistance and are thus implicated in type 2 diabetes (T2D). This complex disease involves systemic metabolic changes, and their elucidation at the systems level requires genome-wide data and biological networks. Genome-scale metabolic models (GEMs) provide a network context for the integration of high-throughput data. We generated myocyte-specific RNA-sequencing data and investigated their correlation with proteome data. Thes ...[more]