Dataset Information
Wu2011 - Influenza-specific CD8+ T cells
Ontology highlight
ABSTRACT:
SUBMITTER: 
Alain Leblanc
PROVIDER: MODEL1504160000 | BioModels | 2016-02-10
REPOSITORIES: BioModels
Publications
Modeling of influenza-specific CD8+ T cells during the primary response indicates that the spleen is a major source of effectors.
Journal of immunology (Baltimore, Md. : 1950) 20110923 9
The biological parameters that determine the distribution of virus-specific CD8(+) T cells during influenza infection are not all directly measurable by experimental techniques but can be inferred through mathematical modeling. Mechanistic and semimechanistic ordinary differential equations were developed to describe the expansion, trafficking, and disappearance of activated virus-specific CD8(+) T cells in lymph nodes, spleens, and lungs of mice during primary influenza A infection. An intensiv ...[more]
