Ontology highlight
ABSTRACT:
SUBMITTER: Ludovic Cottret
PROVIDER: MODEL1710170000 | BioModels | 2023-11-10
REPOSITORIES: BioModels
Peyraud Rémi R Cottret Ludovic L Marmiesse Lucas L Genin Stéphane S
Nature communications 20180129 1
Robustness is a key system-level property of living organisms to maintain their functions while tolerating perturbations. We investigate here how a regulatory network controlling multiple virulence factors impacts phenotypic robustness of a bacterial plant pathogen. We reconstruct a cell-scale model of Ralstonia solanacearum connecting a genome-scale metabolic network, a virulence macromolecule network, and a virulence regulatory network, which includes 63 regulatory components. We develop in si ...[more]