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Rozendaal2018 - Model Integrating Glucose and Lipid Dynamics

ABSTRACT: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006145

SUBMITTER: Rozendaal YJW

PROVIDER: MODEL1803200001 | BioModels | 2019-02-07

REPOSITORIES: BioModels

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Publications

In vivo and in silico dynamics of the development of Metabolic Syndrome.

Rozendaal Yvonne J W YJW Wang Yanan Y Paalvast Yared Y Tambyrajah Lauren L LL Li Zhuang Z Willems van Dijk Ko K Rensen Patrick C N PCN Kuivenhoven Jan A JA Groen Albert K AK Hilbers Peter A J PAJ van Riel Natal A W NAW

PLoS computational biology 20180607 6

The Metabolic Syndrome (MetS) is a complex, multifactorial disorder that develops slowly over time presenting itself with large differences among MetS patients. We applied a systems biology approach to describe and predict the onset and progressive development of MetS, in a study that combined in vivo and in silico models. A new data-driven, physiological model (MINGLeD: Model INtegrating Glucose and Lipid Dynamics) was developed, describing glucose, lipid and cholesterol metabolism. Since class ...[more]

PMID: 29879115

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