Dataset Information
Hodgson2018 - TGFbeta signalling and inflammatory response
Ontology highlight
ABSTRACT:
SUBMITTER: 
David hodgson
PROVIDER: MODEL1805080001 | BioModels | 2019-01-30
REPOSITORIES: BioModels
Publications
Systems biology reveals how altered TGFβ signalling with age reduces protection against pro-inflammatory stimuli.
PLoS computational biology 20190124 1
Osteoarthritis (OA) is a degenerative condition caused by dysregulation of multiple molecular signalling pathways. Such dysregulation results in damage to cartilage, a smooth and protective tissue that enables low friction articulation of synovial joints. Matrix metalloproteinases (MMPs), especially MMP-13, are key enzymes in the cleavage of type II collagen which is a vital component for cartilage integrity. Transforming growth factor beta (TGFβ) can protect against pro-inflammatory cytokine-me ...[more]
