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Parmar2019 - Iron Mouse PV3

ABSTRACT: Iron Mouse PV3 "A computational model to understand mouse iron physiology and diseases" By Jignesh Parmar and Pedro Mendes Base model This is a dynamic model of iron distribution in mice, covering seven compartments: plasma, bone marrow, red blood cells (RBC), spleen, duodenum, liver, and the rest of the body . This is mostly a physiological model with regulation by hepcidin and erythropoietin, including only a minimal amount of molecular details. This version of the model does not include the radioactive-labelled tracer iron species that were used for parameter estimation (that is included in a separate file). This model has all parameter values already set to the best estimates obtained with the model with radioactive tracer. This model is useful to study the steady state properties of the system and as a basis for various types of simulation. Model validation was carried out with other model files that were derived from this one and where certain parameters were altered or new interventions added.

SUBMITTER: Pedro Mendes  

PROVIDER: MODEL1805140003 | BioModels | 2022-09-16

REPOSITORIES: BioModels

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A computational model to understand mouse iron physiology and disease.

Parmar Jignesh H JH   Mendes Pedro P  

PLoS computational biology 20190104 1

It is well known that iron is an essential element for life but is toxic when in excess or in certain forms. Accordingly there are many diseases that result directly from either lack or excess of iron. Yet many molecular and physiological aspects of iron regulation have only been discovered recently and others are still elusive. There is still no good quantitative and dynamic description of iron absorption, distribution, storage and mobilization that agrees with the wide array of phenotypes pres  ...[more]

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