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Khanin1998 - Mathematical Model of Blood Coagulation Prothrombin Time Test

ABSTRACT: Blood coagulation model for prothrombin time test.

SUBMITTER: Matthew Roberts  

PROVIDER: MODEL1806120001 | BioModels | 2018-06-12

REPOSITORIES: BioModels

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Publications

Mathematical model for the blood coagulation prothrombin time test.

Khanin M A MA   Rakov D V DV   Kogan A E AE  

Thrombosis research 19980301 5

A mathematical model for the prothrombin time test is proposed. The time course of clotting factor activation during coagulation was calculated, and the sensitivity of the test to a decrease in the concentrations of coagulation proteins or their activities was studied. The model predicts that only severe coagulation disorders connected with a more than five-fold decrease in the concentrations or activities of the blood coagulation factors can be revealed by the test. ...[more]