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Mishra2018 - enhancing sorafenib efficacy by co-target identification through quantitive modelling approach

ABSTRACT: Kinetic model of GSHnet of different HCC etiological conditions.

SUBMITTER: Madhulika Mishra

PROVIDER: MODEL1808060001 | BioModels | 2019-08-07

REPOSITORIES: BioModels

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Identification of a co-target for enhancing efficacy of sorafenib in HCC through a quantitative modeling approach.

Mishra Madhulika M Jayal Priyanka P Karande Anjali A AA Chandra Nagasuma N

The FEBS journal 20180906 21

Sorafenib (SFB), a multi-kinase inhibitor, is the only approved drug for treating hepatocellular carcinoma (HCC). However, SFB shows low efficacy in many cases. HCC related mortality therefore remains to be high worldwide. SFB, a multi-kinase inhibitor is also known to modulate the redox homeostasis in cancer cells. To understand the effect of SFB on the redox status, a quantitative understanding of the system is necessary. Kinetic modeling of the relevant pathways is a useful approach for obtai ...[more]

PMID: 30136368

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