Ontology highlight
ABSTRACT:
SUBMITTER: Matthew Roberts
PROVIDER: MODEL1808160001 | BioModels | 2018-08-16
REPOSITORIES: BioModels
Terentyeva Vladislava A VA Sveshnikova Anastasia N AN Panteleev Mikhail A MA
Journal of theoretical biology 20150714
Surface-induced activation of factor XII is critical part of the intrinsic pathway of blood coagulation. The mechanism of this process remains unclear: in particular, it is not known whether the initial amounts of factor XIIa, an active form of factor XII, are produced purely by factor XII contacting a surface or if traces of factor XIIa pre-exist. Furthermore, it is not known whether factor XII first has to bind to a surface before it can interact with the surface-bound factor XIIa in a two-dim ...[more]