Dataset Information


Panteleev2010 - Blood Coagulation: Full Model

ABSTRACT: Full and reduced mathematical model of blood coagulation focusing on fibrin formation and the response to varied TF and V.

SUBMITTER: Krishna Kumar Tiwari  

PROVIDER: MODEL1808160002 | BioModels | 2018-08-16


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Task-oriented modular decomposition of biological networks: trigger mechanism in blood coagulation.

Panteleev Mikhail A MA   Balandina Anna N AN   Lipets Elena N EN   Ovanesov Mikhail V MV   Ataullakhanov Fazoil I FI  

Biophysical journal 20100501 9

Analysis of complex time-dependent biological networks is an important challenge in the current postgenomic era. We propose a middle-out approach for decomposition and analysis of complex time-dependent biological networks based on: 1), creation of a detailed mechanism-driven mathematical model of the network; 2), network response decomposition into several physiologically relevant subtasks; and 3), subsequent decomposition of the model, with the help of task-oriented necessity and sensitivity a  ...[more]

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