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Naski1991 - alpha-Thrombin-catalyzed conversion of Fibrinogen

ABSTRACT: Mathematical model of blood coagulation factor alpha-thrombin and conversion of fibrinogen to fibrin with ATIII inhibition.

SUBMITTER: Matthew Roberts

PROVIDER: MODEL1808210002 | BioModels | 2018-08-21

REPOSITORIES: BioModels

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A kinetic model for the alpha-thrombin-catalyzed conversion of plasma levels of fibrinogen to fibrin in the presence of antithrombin III.

Naski M C MC Shafer J A JA

The Journal of biological chemistry 19910701 20

In this study we report a kinetic model for the alpha-thrombin-catalyzed production of fibrin I and fibrin II at pH 7.4, 37 degrees C, gamma/2 0.17. The fibrin is produced by the action of human alpha-thrombin on plasma levels of human fibrinogen in the presence of the major inhibitor of alpha-thrombin in plasma, antithrombin III (AT). This model quantitatively accounts for the time dependence of alpha-thrombin-catalyzed release of fibrinopeptides A and B concurrent with the inactivation of alph ...[more]

PMID: 2071587

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