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Naski1991 - alpha-Thrombin-catalyzed conversion of Fibrinogen


ABSTRACT: Mathematical model of blood coagulation factor alpha-thrombin and conversion of fibrinogen to fibrin with ATIII inhibition.

SUBMITTER: Matthew Roberts  

PROVIDER: MODEL1808210002 | BioModels | 2018-08-21

REPOSITORIES: BioModels

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A kinetic model for the alpha-thrombin-catalyzed conversion of plasma levels of fibrinogen to fibrin in the presence of antithrombin III.

Naski MC   Shafer JA  

The Journal of biological chemistry 19910701 20


In this study we report a kinetic model for the alpha-thrombin-catalyzed production of fibrin I and fibrin II at pH 7.4, 37 degrees C, gamma/2 0.17. The fibrin is produced by the action of human alpha-thrombin on plasma levels of human fibrinogen in the presence of the major inhibitor of alpha-thrombin in plasma, antithrombin III (AT). This model quantitatively accounts for the time dependence of alpha-thrombin-catalyzed release of fibrinopeptides A and B concurrent with the inactivation of alph  ...[more]

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