Dataset Information

Zhang2018 - Cell cycle commitment in hypoxia

ABSTRACT: Does not reproduce publication figure 3

SUBMITTER: Ashley Xavier

PROVIDER: MODEL1812060002 | BioModels | 2018-12-06

REPOSITORIES: BioModels

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Publications

Mathematical modelling of interacting mechanisms for hypoxia mediated cell cycle commitment for mesenchymal stromal cells.

Zhang Bo B Ye Hua H Yang Aidong A

BMC systems biology 20180402 1

<h4>Background</h4>Existing experimental data have shown hypoxia to be an important factor affecting the proliferation of mesenchymal stromal cells (MSCs), but the contrasting observations made at various hypoxic levels raise the questions of whether hypoxia accelerates proliferation, and how. On the other hand, in order to meet the increasing demand of MSCs, an optimised bioreactor control strategy is needed to enhance in vitro production.<h4>Results</h4>A comprehensive, single-cell mathematica ...[more]

PMID: 29606139

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