Ontology highlight
ABSTRACT:
SUBMITTER: Kirsten Jenkins
PROVIDER: MODEL1901210001 | BioModels | 2019-11-29
REPOSITORIES: BioModels
Moreno David F DF Jenkins Kirsten K Morlot Sandrine S Charvin Gilles G Csikasz-Nagy Attila A Aldea Martí M
eLife 20190913
Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct cause-effect relationships are not well understood. We show that most yeast cells arrest in G1 before death with low nuclear levels of Cln3, a key G1 cyclin extremely sensitive to chaperone status. Chaperone availability is seriously compromised in aged cells, and the G1 arrest coincides with massive aggregation of a metastable chaperone-activity reporter. Moreover, G1-cyclin overexpression increases lifespan in ...[more]