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Heiland2019 - Two compartment model of NAD biosynthesis and consumption

ABSTRACT: The model is based on MODEL1905220001 but has two compartments that have different composition of the biosynthetic enzymes NADA and NamPT. One compartment contains in addition NNMT, the other one does not. Both compartments are competing for a common Nam source.

SUBMITTER: Ines Heiland

PROVIDER: MODEL1905220002 | BioModels | 2019-08-01

REPOSITORIES: BioModels

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	MODEL1905220002?filename=data_S3_competition_model.xml	Xml

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Publications

Weak coupling of ATP hydrolysis to the chemical equilibrium of human nicotinamide phosphoribosyltransferase.

Burgos Emmanuel S ES Schramm Vern L VL

Biochemistry 20080930 42

Human nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12) catalyzes the reversible synthesis of nicotinamide mononucleotide (NMN) and inorganic pyrophosphate (PP i) from nicotinamide (NAM) and alpha- d-5-phosphoribosyl-1-pyrophosphate (PRPP). NAMPT, by capturing the energy provided by its facultative ATPase activity, allows the production of NMN at product:substrate ratios thermodynamically forbidden in the absence of ATP. With ATP hydrolysis coupled to NMN synthesis, the catalytic effic ...[more]

PMID: 18823127

Publication: 1/10

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Heiland2019 - Two compartment model of NAD biosynthesis and consumption

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