Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: MTBLS1015
SUBMITTER: Partho Sen
PROVIDER: MODEL1905270001 | BioModels | 2020-03-11
REPOSITORIES: BioModels
Sen Partho P Dickens Alex M AM López-Bascón María Asunción MA Lindeman Tuomas T Kemppainen Esko E Lamichhane Santosh S Rönkkö Tuukka T Ilonen Jorma J Toppari Jorma J Veijola Riitta R Hyöty Heikki H Hyötyläinen Tuulia T Knip Mikael M Orešič Matej M
Diabetologia 20200211 5
<h4>Aims/hypothesis</h4>Previous metabolomics studies suggest that type 1 diabetes is preceded by specific metabolic disturbances. The aim of this study was to investigate whether distinct metabolic patterns occur in peripheral blood mononuclear cells (PBMCs) of children who later develop pancreatic beta cell autoimmunity or overt type 1 diabetes.<h4>Methods</h4>In a longitudinal cohort setting, PBMC metabolomic analysis was applied in children who (1) progressed to type 1 diabetes (PT1D, n = 34 ...[more]