Dataset Information
Ghaffari2019 - Thrombomodulin Gene Expression after Retinoic Acid Treatment for Cancer Patients with Coagulation Disorders
Ontology highlight
ABSTRACT:
SUBMITTER: 
Matthew Roberts
PROVIDER: MODEL1907140001 | BioModels | 2020-03-16
REPOSITORIES: BioModels
Publications
Analysis of the role of thrombomodulin in all-trans retinoic acid treatment of coagulation disorders in cancer patients.
Theoretical biology & medical modelling 20190214 1
<h4>Background</h4>Clinical studies have shown that all-trans retinoic acid (RA), which is often used in treatment of cancer patients, improves hemostatic parameters and bleeding complications such as disseminated intravascular coagulation (DIC). However, the mechanisms underlying this improvement have yet to be elucidated. In vitro studies have reported that RA upregulates thrombomodulin (TM) expression on the endothelial cell surface. The objective of this study was to investigate how and to w ...[more]
