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Arciero2004 - A mathematical model of tumor-immune evasion and siRNA treatment

ABSTRACT: This is a mathematical model consisting of a system of nonlinear ordinary differential equations describing tumor cells and immune effectors, as well as the immuno-stimulatory and suppressive cytokines IL-2 and TGF-Beta.

SUBMITTER: Johannes Meyer

PROVIDER: MODEL1907310002 | BioModels | 2019-12-18

REPOSITORIES: BioModels

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Modeling immunotherapy of the tumor-immune interaction.

Kirschner D D Panetta J C JC

Journal of mathematical biology 19980901 3

A number of lines of evidence suggest that immunotherapy with the cytokine interleukin-2 (IL-2) may boost the immune system to fight tumors. CD4+ T cells, the cells that orchestrate the immune response, use these cytokines as signaling mechanisms for immune-response stimulation as well as lymphocyte stimulation, growth, and differentiation. Because tumor cells begin as 'self', the immune system may not respond in an effective way to eradicate them. Adoptive cellular immunotherapy can potentially ...[more]

PMID: 9785481

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