Ontology highlight
ABSTRACT:
SUBMITTER: Johannes Meyer
PROVIDER: MODEL1909090003 | BioModels | 2019-09-09
REPOSITORIES: BioModels
Shariatpanahi Seyed Peyman SP Shariatpanahi Seyed Pooya SP Madjidzadeh Keivan K Hassan Moustapha M Abedi-Valugerdi Manuchehr M
Journal of theoretical biology 20180111
Myeloid-derived suppressor cells (MDSCs) belong to immature myeloid cells that are generated and accumulated during the tumor development. MDSCs strongly suppress the anti-tumor immunity and provide conditions for tumor progression and metastasis. In this study, we present a mathematical model based on ordinary differential equations (ODE) to describe tumor-induced immunosuppression caused by MDSCs. The model consists of four equations and incorporates tumor cells, cytotoxic T cells (CTLs), natu ...[more]