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Shariatpanahi2018 - Mathematical modeling of tumor-induced immunosuppression by myeloid-derived suppressor cells


ABSTRACT: This is a ODE-based mathematical model featuring equations describing the dynamics of tumor cells, cytotoxic T cells, natural killer cells, and myeloid-derived suppressor cells (MDSCs) that together describe the tumor-induced immunosuppression caused by MDSCs.

SUBMITTER: Johannes Meyer  

PROVIDER: MODEL1909090003 | BioModels | 2019-09-09

REPOSITORIES: BioModels

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Mathematical modeling of tumor-induced immunosuppression by myeloid-derived suppressor cells: Implications for therapeutic targeting strategies.

Shariatpanahi Seyed Peyman SP   Shariatpanahi Seyed Pooya SP   Madjidzadeh Keivan K   Hassan Moustapha M   Abedi-Valugerdi Manuchehr M  

Journal of theoretical biology 20180111


Myeloid-derived suppressor cells (MDSCs) belong to immature myeloid cells that are generated and accumulated during the tumor development. MDSCs strongly suppress the anti-tumor immunity and provide conditions for tumor progression and metastasis. In this study, we present a mathematical model based on ordinary differential equations (ODE) to describe tumor-induced immunosuppression caused by MDSCs. The model consists of four equations and incorporates tumor cells, cytotoxic T cells (CTLs), natu  ...[more]

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