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Rangel-Reyes2017 - Dendritic Immunotherapy Improvement for an Optimal Control Murine Model

ABSTRACT: This is a mathematical model provides a platform for investigating the efficacy of dendritic cell vaccines during cancer treatment while accounting for obstacles such as immunosuppression and poor transference to the lymphatic system.

SUBMITTER: Johannes Meyer

PROVIDER: MODEL1909160002 | BioModels | 2019-09-16

REPOSITORIES: BioModels

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Dendritic Immunotherapy Improvement for an Optimal Control Murine Model.

Rangel-Reyes J C JC Chimal-Eguía J C JC Castillo-Montiel E E

Computational and mathematical methods in medicine 20170820

Therapeutic protocols in immunotherapy are usually proposed following the intuition and experience of the therapist. In order to deduce such protocols mathematical modeling, optimal control and simulations are used instead of the therapist's experience. Clinical efficacy of dendritic cell (DC) vaccines to cancer treatment is still unclear, since dendritic cells face several obstacles in the host environment, such as immunosuppression and poor transference to the lymph nodes reducing the vaccine ...[more]

PMID: 28912828

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